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Year Number of Results
2003 2
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2005 1
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2010 1
2012 1
2013 1
2014 3
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2019 5
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45 results

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USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer.
Xie H, Zhou J, Liu X, Xu Y, Hepperla AJ, Simon JM, Wang T, Yao H, Liao C, Baldwin AS, Gong K, Zhang Q. Xie H, et al. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2119854119. doi: 10.1073/pnas.2119854119. Epub 2022 Aug 29. Proc Natl Acad Sci U S A. 2022. PMID: 36037364 Free PMC article.
VHL is the component of an E3 ligase complex that promotes the ubiquitination and degradation of hypoxia inducible factor alpha (HIF-alpha) (including HIF1alpha and HIF2alpha) and Zinc Fingers And Homeoboxes 2 (ZHX2). Our recent research showed …
VHL is the component of an E3 ligase complex that promotes the ubiquitination and degradation of hypoxia inducible factor alpha (HIF-alpha) …
Zinc fingers and homeoboxes 2 is required for diethylnitrosamine-induced liver tumor formation in C57BL/6 mice.
Jiang J, Turpin C, Qiu GS, Xu M, Lee E, Hinds TD Jr, Peterson ML, Spear BT. Jiang J, et al. Hepatol Commun. 2022 Dec;6(12):3550-3562. doi: 10.1002/hep4.2106. Epub 2022 Oct 4. Hepatol Commun. 2022. PMID: 36194180 Free PMC article.
Liver cancer, comprised primarily of hepatocellular carcinoma (HCC), is the third leading cause of cancer deaths worldwide and increasing in Western countries. We previously identified the transcription factor zinc fingers and homeoboxes 2 (Zhx2 …
Liver cancer, comprised primarily of hepatocellular carcinoma (HCC), is the third leading cause of cancer deaths worldwide and increasing in …
The zinc fingers and homeoboxes 2 protein ZHX2 and its interacting proteins regulate upstream pathways in podocyte diseases.
Macé C, Del Nogal Avila M, Marshall CB, Kharlyngdoh J, Das R, Molina-Jijon E, Donoro Blazquez H, Shastry S, Soria E, Wetzels J, Dijkman H, Avila-Casado C, Clement LC, Chugh SS. Macé C, et al. Kidney Int. 2020 Apr;97(4):753-764. doi: 10.1016/j.kint.2019.11.011. Epub 2019 Nov 26. Kidney Int. 2020. PMID: 32059999 Free PMC article.
Zinc fingers and homeoboxes (ZHX) proteins are heterodimeric transcriptional factors largely expressed at the cell membrane in podocytes in vivo. We found ZHX2-based heterodimers in podocytes, with ZHX2-ZHX1 predominantly at the cell memb …
Zinc fingers and homeoboxes (ZHX) proteins are heterodimeric transcriptional factors largely expressed at the ce …
Zhx2 (zinc fingers and homeoboxes 2) regulates major urinary protein gene expression in the mouse liver.
Jiang J, Creasy KT, Purnell J, Peterson ML, Spear BT. Jiang J, et al. J Biol Chem. 2017 Apr 21;292(16):6765-6774. doi: 10.1074/jbc.M116.768275. Epub 2017 Mar 3. J Biol Chem. 2017. PMID: 28258223 Free PMC article.
We previously identified Zhx2 (zinc fingers and homeoboxes 2) as a regulator of numerous liver-enriched genes. ...In contrast to previously identified Zhx2 targets that appear to be repressed by Zhx2, Mup genes are po …
We previously identified Zhx2 (zinc fingers and homeoboxes 2) as a regulator of numerous liver-enriched …
Zinc fingers and homeoboxes 2 inhibition could suppress the proliferation of ovarian cancer cells by apoptosis pathway.
Ding R, Shi H, Guo Y, Zeng W, Fan J. Ding R, et al. Clin Transl Oncol. 2023 Jul;25(7):2116-2126. doi: 10.1007/s12094-023-03090-z. Epub 2023 Feb 6. Clin Transl Oncol. 2023. PMID: 36746874
OBJECTIVE: The Zinc fingers and homeoboxes (ZHX) protein family has been reported to be involved in tumor development; however, it remains controversial whether these proteins can act as promoters or inhibitors of cancer development. ...Patient …
OBJECTIVE: The Zinc fingers and homeoboxes (ZHX) protein family has been reported to be involved in tumor develo …
Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.
Creasy KT, Jiang J, Ren H, Peterson ML, Spear BT. Creasy KT, et al. Gene Expr. 2016;17(1):7-17. doi: 10.3727/105221616X691712. Epub 2016 May 17. Gene Expr. 2016. PMID: 27197076 Free PMC article.
An exception to this pattern is seen in BALB/cJ mice, where male hepatic Cyp2a4 mRNA levels are substantially elevated compared to male mice of other strains. The Zinc fingers and homeoboxes 2 (Zhx2) protein governs the silencing of sever …
An exception to this pattern is seen in BALB/cJ mice, where male hepatic Cyp2a4 mRNA levels are substantially elevated compared to male mice …
ZHX2 in health and disease.
Li N, Wu Z, Ma C. Li N, et al. Front Oncol. 2022 Nov 18;12:1038890. doi: 10.3389/fonc.2022.1038890. eCollection 2022. Front Oncol. 2022. PMID: 36465389 Free PMC article. Review.
As a transcriptional factor and the negative regulator of alpha fetal protein (AFP), Zinc fingers and homeoboxes 2 (ZHX2) has a well-established role in protection against hepatocellular carcinoma (HCC). ...This comprehensive review empha …
As a transcriptional factor and the negative regulator of alpha fetal protein (AFP), Zinc fingers and homeoboxes …
Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response.
Tan S, Wang Z, Li N, Guo X, Zhang Y, Ma H, Peng X, Zhao Y, Li C, Gao L, Li T, Liang X, Ma C. Tan S, et al. Cell Death Differ. 2023 Sep;30(9):2104-2119. doi: 10.1038/s41418-023-01202-4. Epub 2023 Aug 15. Cell Death Differ. 2023. PMID: 37582865
Macrophages are usually educated to tumor-associated macrophages (TAMs) in cancer with pro-tumor functions by tumor microenvironment (TME) and TAM reprogramming has been proposed as a potential tumor immunotherapy strategy. We recently demonstrated the critical role of Zinc …
Macrophages are usually educated to tumor-associated macrophages (TAMs) in cancer with pro-tumor functions by tumor microenvironment (TME) a …
The transcription factor zinc fingers and homeoboxes 2 alleviates NASH by transcriptional activation of phosphatase and tensin homolog.
Zhao Y, Gao L, Jiang C, Chen J, Qin Z, Zhong F, Yan Y, Tong R, Zhou M, Yuan A, Pu J. Zhao Y, et al. Hepatology. 2022 Apr;75(4):939-954. doi: 10.1002/hep.32165. Epub 2022 Feb 16. Hepatology. 2022. PMID: 34545586
A large and growing unmet therapeutic need for this condition reflects incomplete understanding of its pathogenesis. In the current study, we identified a transcription factor, zinc fingers and homeoboxes 2 (ZHX2), in hepatocytes as a protective …
A large and growing unmet therapeutic need for this condition reflects incomplete understanding of its pathogenesis. In the current study, w …
The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3.
Kawata H, Yamada K, Shou Z, Mizutani T, Miyamoto K. Kawata H, et al. Gene. 2003 Dec 24;323:133-40. doi: 10.1016/j.gene.2003.09.013. Gene. 2003. PMID: 14659886
Human zinc-fingers and homeoboxes (ZHX) 1, ZHX2 and ZHX3, members of the ZHX family, contain two Cys(2)-His(2)-type zinc-finger motifs and five homeodomains (HDs). ...The mouse ZHX2 and ZHX3 proteins consist of 836 an …
Human zinc-fingers and homeoboxes (ZHX) 1, ZHX2 and ZHX3, members of the ZHX family, contain two Cys(2)-H …
45 results